FACTORS INFLUENCING ADHERENCE TO HORMONAL THERAPY IN BREAST CANCER PATIENTS: A SCOPING REVIEW

Abstract

Background: Breast cancer is the most common cancer among women worldwide, with rising incidence rates. Hormonal therapy is essential in treating hormone receptor-positive breast cancer, yet adherence remains a challenge. Non-adherence increases the risk of recurrence and negatively affects outcomes. This review explores factors influencing adherence to hormonal therapy in breast cancer patients, Methods: A scoping review was conducted by systematically analyzing studies published from 2015 to 2025. Literature was sourced from PubMed, Scopus, Web of Science, Google Scholar, ScienceDirect, and DOAJ using Boolean keywords: ("hormonal therapy adherence" OR "compliance") AND ("breast cancer") AND ("factors" OR "determinants") AND ("review"). Studies discussing factors affecting hormonal therapy adherence were selected based on predefined inclusion and exclusion criteria, Results: Sixteen studies were included. The most frequently reported influencing factors were patient-related (75%), followed by disease-related (62.5%), clinical (56.25%), and demographic (50%). Healthcare provider-related (43.75%) and family-related (37.5%) factors also played significant roles in adherence, Conclusions: Adherence to hormonal therapy is shaped by various interrelated factors. Comprehensive, targeted interventions are needed to improve adherence and support better quality of life and treatment outcomes for breast cancer patients.